Biochemistry Symposium

Biochemistry & Biophysics Symposium
Dr. Rajeev Prabhakar, Organizer

Friday May 13th Biochemistry & Biophysics I Presentations

Time	Location	Presenter	Abstract Title
8:55AM-9:00AM	Edinburgh X	Rajeev Prabhakar	INTRODUCTION
9:00AM - 9:25AM	Edinburgh X	Alexander Angerhofer	EPR AND ENDOR EXPERIMENTS ON OXALATE DECARBOXYLASE
9:25AM - 9:50AM	Edinburgh X	Randy Larsen	TIME RESOLVED MOLAR VOLUME AND ENTHALPY CHANGES ASSOCIATED WITH FAST FOLDING IN HORSE HEART CYTOCHROME C AT HIGH pH
9:50AM - 10:15AM	Edinburgh X	Nigel Richards	ASPARAGINE BIOSYNTHESIS AND ASPARAGINASE-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA: STRUCTURE-BASED METHODS FOR INHIBITOR DISCOVERY
10:15AM - 10:35AM	Edinburgh X	Mioara Larion	CONFORMATIONAL HETEROGENEITY OF HUMAN PANCREATIC GLUCOKINASE IN THE ABSENCE AND PRESENCE OF GLUCOSE
10:35AM -11:00AM	Edinburgh Foyer	MID-MORNING BREAK
11:00AM - 11:25AM	Edinburgh X	Roger Leblanc	FLUORESCENCE-BASED DETECTION OF HUMAN CARDIAC TROPONIN I USING A CHEMICALLY-ATTACHED MUTANT ANTIBODY MODIFIED QUARTZ SLIDE
11:25AM - 11:50AM	Edinburgh X	Igor Lednev	ULTRAVIOLET RAMAN SPECTROSCOPY FOR CHARACTERIZING AMYLOID FIBRIL STRUCTURE AND DYNAMICS
11:50AM - 12:10PM	Edinburgh X	Andrew Terentis	A CONFOCAL RAMAN MICROSCOPY STUDY OF CELL PENETRATING PEPTIDE UPTAKE IN LIVE MELANOMA CELLS

Friday May 13th Biochemistry & Biophysics II Presentations

Time	Location	Presenter	Abstract Title
1:30PM - 1:55PM	Edinburgh X	Amjad Farooq	BINDING OF THE ERA NUCLEAR RECEPTOR TO DNA IS COUPLED TO PROTON UPTAKE
1:55PM - 2:15PM	Edinburgh X	Luisana Astudillo	TIME-RESOLVED THERMODYNAMICS OF CO BINDING TO NEUROGLOBIN
2:15PM - 2:40PM	Edinburgh X	Giovanni Gadda	MECHANISTIC INVESTIGATION OF D-ARGININE DEHYDROGENASE FROM PSEUDOMONAS AERUGINOSA
2:40PM - 3:05PM	Edinburgh X	Henry Lee Woodcock	MULTISCALE MODELING AS AN AVENUE TO EXPLORE ENZYME STRUCTURE / FUNCTION RELATIONSHIPS
3:05PM - 3:30PM	Edinburgh Foyer	MID-AFTERNOON BREAK
3:30PM - 3:55PM	Edinburgh X	David Merkler	BIOTINYLATED, PHOTOACTIVABLE ADENOSINE ANALOGS AS PROTEOMIC PROFILING TOOLS
3:55PM - 4:20PM	Edinburgh X	Donald Hamelberg	ATOMISTIC BASIS FOR THE ON-OFF SIGNALING MECHANISM IN RIBOSWITCHES
4:20PM - 4:40PM	Edinburgh X	Lorraine Clark	BIOSYNTHESIS OF AZASUGARS
4:40PM - 5:05PM	Edinburgh X	Arjan van der Vaart	THE FLEXIBILITY OF SMALL-LENGTH DNA

Saturday May 14th Design of Bio-inspired Metal Based Peptidases Presentations

Time	Location	Presenter	Abstract Title
9:00AM - 9:25AM	Edinburgh X	Gail Fanucci	PROBING EFFECTS OF AMINO ACID SUBSTITUTIONS ON HIV-1 PROTEASE CONFORMATIONAL FLEXIBILITY WITH PULSED EPR SPECTROSCOPY
9:25AM - 9:50AM	Edinburgh X	Ben Dunn	STRUCTURE AND ACTIVE SITE INTERACTIONS OF THE ASPARTIC PROTEINASES FROM THE MALARIAL PARASITE
9:50AM - 10:10AM	Edinburgh X	Arghya Barman	COMPUTATIONAL INSIGHTS INTO SUBSTRATE RECOGNITION AND REACTIVITY OF ß-SECRETASE (BACE1) ENZYME
10:10AM - 10:35AM	EdinburghX	Qing-Xiang Amy Sang	COMPLEX ROLES OF HUMAN ENDOMETASE/MATRILYSIN-2 IN CANCER INVASION, PROGRESSION, AND INFLAMMATION
10:35AM -11:00AM	Edinburgh Foyer	MID-MORNING BREAK
11:00AM - 11:25AM	Edinburgh X	Malcolm Leissring	INSULIN-DEGRADING ENZYME AS A THERAPEUTIC TARGET FOR THE MANAGEMENT AND PREVENTION OF DIABETES
11:25AM - 12:05AM	Edinburgh X	Gerard Parkin	BIORGANOMETALLIC CHEMISTRY OF MERCURY AND APPROACHES TO DETOXIFICATION

Saturday May 14th Biochemistry & Biophysics III Presentations

Time	Location	Presenter	Abstract Title
1:30PM-1:55PM	Edinburgh X	Vasiliki Lykourinou	METAL COMPLEXES OF A MULTIDENTATE CYCLOPHOSPHAZENE WITH IMIDAZOLE-CONTAINING SIDE CHAINS FOR HYDROLYSES OF PHOSPHOESTERS: A BIMOLECULAR DINUCLEAR PATHWAY
1:55PM - 2:20PM	Edinburgh X	Rajeev Prabhakar	ELUCIDATING MECHANISMS OF METALLOPEPTIDASES AND THEIR SYNTHETIC ANALOGUES
2:20PM - 2:45PM	Edinburgh X	Wei Yang	FURTHER DEVELOPMENT OF ORTHOGONAL SPACE RANDOM WALK BASED METHODS.
2:45PM - 3:05PM	Edinburgh X	Dhruva Chakravorty	MOLECULAR DYNAMICS SIMULATIONS OF THE ZINC SENSOR PROTEIN CZRA
3:00PM - 3:30PM	Edinburgh Foyer	MID-AFTERNOON BREAK
3:30PM - 3:50PM	Edinburgh X	Sai Lakshmana Vankayala	UNLOCKING THE BINDING AND REACTION MECHANISM OF HYDROXYUREA AS A BIOLOGICAL NITRIC OXIDE DONOR
3:50PM - 4:10PM	Edinburgh X	Alix Grimley	GLUCOKINASE ACTIVATION BY THE APOPTOTIC PROTEIN BAD
4:10PM - 4:30PM	Edinburgh X	Shraddha Desai	REGULATION OF CDK7 ACTIVITY THROUGH A PI (3)-KINASE/ PKC-ι MEDIATED CELL PROLIFERATION CASCADE
4:30PM - 4:50PM	Edinburgh X	Kathryn Holder	VISCOSITY EFFECT ON PROTEIN SELF ASSEMBLY, CONFORMATIONAL CHANGE, AND AMYLOID FIBER FORMATION