Dr. Zhu, Wen

Aug 9, 2022

Faculty

FLORIDA STATE / PEOPLE / FACULTY

Dr. Wen Zhu, Assistant Professor

RESEARCH WEBSITE

Professional Preparation/Appointments

Ph. D. Purdue University (2015)
Postdoc, Cardiff University (2016-2017)
Postdoc, University of California Berkeley (2017-2021)
Research Scientist, Astex Pharmaceuticals (2021-2022)

Contact Information

Email	wzhu@chem.fsu.edu
Office	4004 CSL	850.64x.xxxx
Lab	4501 CSL

Programs of Research

Biochemistry

Research Specialties

Bioanalytical, Chemical Biology, Structural Biology, Synthesis and Catalysis

Research Interest

Research in Wen Zhu’s laboratory focuses on translating the fundamental understanding of enzyme catalysis into the knowledge needed for innovative drug discovery. We use genome mining, mechanistic enzymology, structural biology, and biophysical tools to investigate how metallocofactors and protein motions control catalysis.

Faculty Interview

Publications

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Zhu, W.; Walker, L.M.; Tao, L.; et. al. Structural Properties and Catalytic Implications of the SPASM Domain Iron–Sulfur Clusters in Methylorubrum extorquens PqqE. J. Am. Chem. Soc., 2020, 142, 12620–12634.

Tao, L.; Zhu, W.; Klinman, J.P.; Britt, R.D.Electron Paramagnetic Resonance Spectroscopic Identification of the Fe–S Clusters in the SPASM Domain-Containing Radical SAM Enzyme PqqE. Biochemistry, 2020, 58, 5173-5187.

Zhu, W.; Radadiya, A.; Bisson, C.; et al. High-resolution Crystal Structure of Human Asparagine Synthetase Enables Analysis of Inhibitor Binding and Selectivity. Commun. Biol., 2019, 2, 345.

Zhu, W.; Reinhardt, L.A.; Richards, N.G.J. Second-Shell Hydrogen Bond Impacts Transition-State Structure in Bacillus subtilis Oxalate Decarboxylase. Biochemistry, 2018, 57, 3425-3432.

Sheng, X.; Zhu, W.; Huddleston, J. et al. A Combined Experimental-theoretical Study of the LigW-catalyzed Decarboxylation of 5-carboxyvanillate in the Metabolic Pathway for Lignin Degradation. ACS Catalysis, 2017, 7, 4968-4974.